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Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell FunctionJIE GAO; GRAVES, Stephanie; RADTKE, Freddy et al.Cell stem cell. 2009, Vol 4, Num 6, pp 548-558, issn 1934-5909, 11 p.Article

Evaluation of vitamin D3 A-ring analogues as Hedgehog pathway inhibitorsBANERJEE, Upasana; GHOSH, Manuka; HADDEN, M. Kyle et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 3, pp 1330-1334, issn 0960-894X, 5 p.Article

Development of a monoclonal antibody-based ELISA for the hedgehog inhibitors cyclopamine and KAAD-cyclopamineLEE, Stephen T; PANTER, Kip E; GARDNER, Dale R et al.Journal of pharmaceutical and biomedical analysis. 2012, Vol 66, pp 282-286, issn 0731-7085, 5 p.Article

Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMOBIN YANG; HIRD, Alexander W; JANETKA, James W et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 14, pp 4907-4911, issn 0960-894X, 5 p.Article

Modulators of the hedgehog signaling pathwayHERETSCH, Philipp; TZAGKAROULAKI, Lito; GIANNIS, Athanassios et al.Bioorganic & medicinal chemistry. 2010, Vol 18, Num 18, pp 6613-6624, issn 0968-0896, 12 p.Article

Novel oxysterols activate the Hedgehog pathway and induce osteogenesisSTAPPENBECK, Frank; WEI XIAO; EPPERSON, Matt et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 18, pp 5893-5897, issn 0960-894X, 5 p.Article

Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitorGUERLET, Guillaume; SPANGENBERG, Thomas; MANN, Andre et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 12, pp 3608-3612, issn 0960-894X, 5 p.Article

Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)TREMBLAY, Martin R; LESCARBEAU, André; WHITE, Kerry et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 14, pp 4400-4418, issn 0022-2623, 19 p.Article

Determination of unbound vismodegib (GDC-0449) concentration in human plasma using rapid equilibrium dialysis followed by solid phase extraction and high-performance liquid chromatography coupled to mass spectrometryYUZHONG DENG; WONG, Harvey; DEAN, Brian et al.Journal of chromatography. B. 2011, Vol 879, Num 22, pp 2119-2126, issn 1570-0232, 8 p.Article

Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathwayDEBERARDINIS, Albert M; BANERJEE, Upasana; MILLER, Michele et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 14, pp 4859-4863, issn 0960-894X, 5 p.Article

Novel Strategies of Regenerative Medicine Using Chemical CompoundsLASAGNI, L; SAGRINATI, C; RONCONI, E et al.Current medicinal chemistry. 2010, Vol 17, Num 34, pp 4134-4149, issn 0929-8673, 16 p.Article

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathwayBÜTTNER, Anita; SEIFERT, Katrin; COTTIN, Thomas et al.Bioorganic & medicinal chemistry. 2009, Vol 17, Num 14, pp 4943-4954, issn 0968-0896, 12 p.Article

Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathwayMAHINDROO, Neeraj; CONNELLY, Michele C; PUNCHIHEWA, Chandanamali et al.Bioorganic & medicinal chemistry. 2010, Vol 18, Num 13, pp 4801-4811, issn 0968-0896, 11 p.Article

Structure-Activity Relationships and Cancer-Cell Selective Toxicity of Novel Inhibitors of Glioma-Associated Oncogene Homologue 1 (Gli1) Mediated TranscriptionMAHINDROO, Neeraj; CONNELLY, Michele C; PUNCHIHEWA, Chandanamali et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 14, pp 4277-4287, issn 0022-2623, 11 p.Article

Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometryDING, X; CHOU, B; LUM, B. L et al.Journal of chromatography. B. 2010, Vol 878, Num 9-10, pp 785-790, issn 1570-0232, 6 p.Article

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1MALANCONA, Savina; ALTAMURA, Sergio; FILOCAMO, Gessica et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 15, pp 4422-4428, issn 0960-894X, 7 p.Article

Synthesis and cytotoxicity studies of Hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agentsCHENNA, Venugopal; CHAOXIN HU; KHAN, Saeed R et al.Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2014, Vol 49, Num 5-6, pp 641-647, issn 1093-4529, 7 p.Article

1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor ActivityMILLER-MOSLIN, Karen; PEUKERT, Stefan; MIAO DAI et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 13, pp 3954-3968, issn 0022-2623, 15 p.Article

Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonistsLUCAS, Brian S; AARON, Wade; JOHNSON, Michael G et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 12, pp 3618-3622, issn 0960-894X, 5 p.Article

Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitorsONTORIA, Jesus M; LLAUGER BUFI, Laura; JONES, Philip et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 18, pp 5274-5282, issn 0960-894X, 9 p.Article

N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonistsMURAGLIA, Ester; ONTORIA, Jesus M; TORRISI, Caterina et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 18, pp 5283-5288, issn 0960-894X, 6 p.Article

A Bisindole Alkaloid with Hedgehog Signal Inhibitory Activity from the Myxomycete Perichaena chrysospermaSHINTANI, Akinori; TOUME, Kazufumi; RIFAI, Yusnita et al.Journal of natural products (Print). 2010, Vol 73, Num 10, pp 1711-1713, issn 0163-3864, 3 p.Article

Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer AgentsMAHINDROO, Neeraj; PUNCHIHEWA, Chandanamali; FUJII, Naoaki et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 13, pp 3829-3845, issn 0022-2623, 17 p.Article

Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hitBROWN, Matthew L; AARON, Wade; ORF, Jessica et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 18, pp 5206-5209, issn 0960-894X, 4 p.Article